Most people who are regular consumers of psychoactive drugs are not drug addicts, nor will they ever become addicts. In neurobiological theories, non-addictive drug consumption is acknowledged only as a “necessary” prerequisite for addiction, but not as a stable and widespread behavior in its own right. This target article proposes a new neurobiological framework theory for non-addictive psychoactive drug consumption, introducing the concept of “drug instrumentalization.” Psychoactive drugs are consumed for their effects on mental states. Humans are able to learn (...) that mental states can be changed on purpose by drugs, in order to facilitate other, non-drug-related behaviors. We discuss specific “instrumentalization goals” and outline neurobiological mechanisms of how major classes of psychoactive drugs change mental states and serve non-drug-related behaviors. We argue that drug instrumentalization behavior may provide a functional adaptation to modern environments based on a historical selection for learning mechanisms that allow the dynamic modification of consummatory behavior. It is assumed that in order to effectively instrumentalize psychoactive drugs, the establishment of and retrieval from a drug memory is required. Here, we propose a new classification of different drug memory subtypes and discuss how they interact during drug instrumentalization learning and retrieval. Understanding the everyday utility and the learning mechanisms of non-addictive psychotropic drug use may help to prevent abuse and the transition to drug addiction in the future. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Im Fokus dieser ersten Ausgabe des Jahrbuchs HealthCapital Berlin-Brandenburg stehen die Qualifikation sowie die Aus-, Fort- und Weiterbildung einschließlich der akademischen Studiengänge in der Gesundheit. Renommierte Fachleute aus Wirtschaft, Wissenschaft und Praxis berichten über die Entwicklungen, Trends, Praxiserfahrungen und Perspektiven von Qualifizierung sowie über neue Berufs- und Geschäftsfelder. Schwerpunktmäßig werden drei Themenkomplexe behandelt: I. Stand und Perspektive von Fachkräften in Berlin-Brandenburg II. Neue Berufsbilder und Ausbildungsgänge III. Entwicklung und Einführung neuer Gesundheitsstudiengänge Das Jahrbuch HealthCapital Berlin-Brandenburg stellt somit einen aktuellen Überblick (...) über wesentliche Fragen im Zusammenhang mit Qualifikationen, Berufsperspektiven und Arbeitsfeldern in der sich weiter entwickelnden Gesundheitswirtschaft in der Region Berlin-Brandenburg zur Verfügung. (shrink)

Proposing a change to the view on psychoactive drug use in non-addicts touches a sensitive issue because of its potential implications to addiction prevention, therapeutic practice, and drug policy. Commentators raised nine questions that ranged from clarifications, suggested extensions of the model to supporting data previously not regarded, to assumptions on the implications of the model. Here, we take up the suggestions of the commentators to expand the model to behavioral addictions, discuss additional instrumentalization goals, and review the evidence from (...) laboratory animal studies on drug instrumentalization. We consider further the role of sociocultural factors and individual development in the establishment in drug instrumentalization and addiction. Finally, we clarify which implications we think this model may have. We conclude that drug instrumentalization theory can be further applied to other behaviors but will require a sensitive debate when used for drug and addiction policy that directly affects prevention and treatment. (shrink)

Examining relativistic quantum field theory we claim that its description of subnuclear phenomena can be understood most adequately from a semiotic point of view. The paper starts off with a concise and non-technical outline of the firmly based aspects of relativistic quantum field theories. The particular methods, by which these different aspects have to be accessed, can be described as distinct facets of quantum field theory. They differ with respect to the relation between quantum fields and associated particles, and, as (...) we shall argue, should be interpreted as complementary (semiotic) codes. Viewing physical theories as symbolic constructions already came to the fore in the middle of the nineteenth century with the emancipation of the classical theory of the electromagnetic field from mechanics; most notably, as we will point out, with the work of Helmholtz, Hertz, Poincaré, and later on Weyl. Since the epistemological questions posed there are heightened with regard to quantum field theory, we considerably widen their approach and relate it to recent discussions in the philosophy of science, like structural realism and quasi-autonomous domains. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Science has needed a dispassionate valuation of psychoactive drugs, but a motivational analysis should be conducted with respect to long-term reward rather than reproductive fitness. Because of hyperbolic overvaluation of short-term rewards, an individual's valuation depends on the time she forms it and the times she will revisit it, sometimes making her best long-term interest lie in total abstinence.

The drug-reinforcement theory explains why humans get engaged in drug taking behavior. This theory posits that drugs of abuse serve as biological rewards by activating the reinforcement system. Although from a psychological and neurobiological perspective this theory is extremely helpful, it does not tell us about the drug-taking motives and motivation of an individual. The definition of drug instrumentalization goals will improve our understanding of individual drug-taking profiles.

Die Reihe Monographien und Texte zur Nietzsche-Forschung setzt seit mehreren Jahrzehnten die Agenda in der sich stetig verändernden Nietzsche-Forschung. Die Bände sind interdisziplinär und international ausgerichtet und spiegeln das gesamte Spektrum der Nietzsche-Forschung wider, von der Philosophie über die Literaturwissenschaft bis zur politischen Theorie. Die Reihe veröffentlicht Monographien und Sammelbände, die einem strengen Peer-Review-Verfahren unterliegen. Die Buchreihe wird von einem internationalen Redaktionsteam geleitet.

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Arguably, the religious use of hallucinogenic drugs stems from a human search of metaphysical insight rather than from a direct need for cognitive, emotional, social, physical, or sexual improvement. Therefore, the sacramental and spiritual intake of hallucinogenic drugs goes so far beyond other biopsychosocial functions that it deserves its own category in the drug instrumentalization list.

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophische Erörterungen bilden den Schwerpunkt der Nietzsche-Studien. Doch auch die Nietzsche-Rezeptionen anderer Disziplinen wie der Altertumswissenschaften, der Literaturwissenschaft oder der Theologie werden aufgenommen. Die Nietzsche-Studien verstehen sich daher auch nicht als Publikationsorgan einer bestimmten Richtung oder Schule, vielmehr sollen unterschiedliche Interpretationsansätze vorgestellt werden. Das Jahrbuch enthält neben Dokumentationen, Aufsätzen, Vorträgen und Miszellen auch Rezensionen ausgewählter Schriften zu Nietzsche. Jeder Band wird durch ein Namenregister, ein Nietzsche-Stellen-Register und ein Verzeichnis der zitierten oder besprochenen Nietzsche-Literatur erschlossen.

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Philosophical discussions are the main focus of the Nietzsche-Studien. However, the reception of Nietzsche in other disciplines such as classical studies, literary studies or theology are also considered. The Nietzsche-Studien, therefore, serve not just the ideas of any one school or direction, but rather introduce various different approaches to interpreting Nietzsche. The yearbook publishes papers, essays, lectures, short articles, and reviews of selected publications about Nietzsche. Each volume is completed by a name index, an index of Nietzsche quotes and an (...) index of the reviewed or cited Nietzsche literature. (shrink)

Der vorliegende Band umreißt den Einfluß des Philosophen auf das deutsche Geistesleben zwischen 1900 und 1918. Er macht deutlich, daß Nietzsches Einfluß auch nach seinem Tod nicht zurückgegangen ist, sondern, im Gegenteil, ständig zugenommen und immer weitere Kreise erfaßt hat.